Brian Zambrowicz

Dr. Zambrowicz has been our executive vice president and chief scientific officer since February 2007. Dr. Zambrowicz served as our executive vice president of research from August 2002 to February 2007, senior vice president of genomics from February 2000 to August 2002, vice president of research from January 1998 to February 2000, and senior scientist from April 1996 to January 1998. Dr. Zambrowicz has been instrumental in the development of our proprietary gene trapping technology, target validation methods, and small molecule drug discovery platform. Dr. Zambrowicz is responsible for the discovery of new drug candidates and clinical development through Phase 2 human proof-of-concept. Under his direction, Lexicon has knocked out and analyzed nearly 5,000 genes, resulting in more than 100 potential drug targets, and brought multiple clinical candidates into development. With Dr. Sands, he has co-authored numerous scientific and drug development publications focusing on gene knockout technology and drug discovery. Prior to joining Lexicon, Dr. Zambrowicz served as a National Institutes of Health postdoctoral fellow at the Fred Hutchinson Cancer Center in Seattle, Washington, where he studied gene trapping and gene targeting technology. He received his B.S. in biochemistry from the University of Wisconsin. He received his Ph.D. in biochemistry from the University of Washington, where he studied tissue-specific gene regulation using transgenic mice.